Immune Cells Profiles in the Different Sites of COVID-19-Affected Lung Lobes in a Single Patient

Immune Cells Profiles in the Different Sites of COVID-19-Affected Lung Lobes in a Single Patient

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Whereas the COVID-19 disease pathophysiology is under investigation, it is important to identify the pathways of viral transmission and inflammation from the pre-illness to the disease-onset stages.We analyzed five lung lobes from a patient with COVID-19 who finally died after prolonged lung protective ventilation.Pathological examination revealed moderate inflammation in upper lung lobes and uneven yet severe inflammation and diffuse alveolar damage in lower lung lobes.SARS-CoV-2 was detected at Video Pinch Roller higher levels not in severely, but rather moderately inflamed middle lung lobes, and immunohistochemistry and bulk RNA-sequencing results showed that immune cells were detected at higher levels in lower lung lobes.The mRNA expression of cytokine families varied.

We found an increase in keratin 5- or aquaporin 3-expressing basal cells in the severely inflamed lower lung lobes, and the alveolar stromal tissues were filled with them.Thus, this analysis of lung samples from a patient helps to determine the COVID-19 pathophysiology at a specific time point, and the virus localization and inflammatory responses at each site of the lungs provide NULL various important indications.